This Southern Meatloaf Recipe, made with just 5 ingredients, is so easy to make and even more delicious when you have leftovers. It’s a southern staple in my house, especially when you put a piece between two slices of white bread the next day for lunch!

Meatloaf is one of those meals that you’ll see on our weekly menu at least twice a month. It’s an easy meal for me to prepare and one that our entire family loves. Let me be honest though.

Growing up I used to shudder at the thoughts of meatloaf. I only began liking the menu staple a few years ago when I combined a few recipes to make a dry, but not too dry version of the meal.

I feel like my meatloaf version is one of the best I’ve ever tried and it’s so easy with just 5 ingredients!

This one is easy to make too! It comes together in literally 10 minutes and bakes for about an hour which gives you plenty of time to do other things instead of standing by the stove. If you’re new here, believe me, I only make easy recipes.

What’s in this 5-ingredient southern meatloaf recipe:

• Ground Beef
• Onion
• Breadcrumbs
• Milk or Almond Milk
• Egg [optional]
• Worcestershire Sauce [optional]
• Salt & Pepper

Now, you may notice that my list is a little longer than 5 ingredients, but that’s because a few are optional.

If you are looking for an egg substitute for meatloaf, you can simply eliminate the egg in this recipe. The breadcrumbs will hold the meatloaf together just fine. Egg in meatloaf is used as a binding agent, but so are breadcrumbs.

In fact, if you want to really make this a Southern meatloaf, you could use saltine crackers. That’s what my grandmother always used in her classic meatloaf recipe.

Honestly, this southern meatloaf recipe can be made with so many variations:

• onion powder or salt instead of chopped onion
• using breadcrumbs as an egg substitute for meatloaf
• almond milk as a milk substitute
• ground turkey instead of ground beef
• a dash of garlic powder for extra flavor

I feel like that’s the sign of a great southern recipe – it can be made your own with just a few alterations and it will still come out tasting great!

You can also make this southern meatloaf recipe without ketchup. You could add barbecue sauce on top or just skip the topping altogether, if you choose.

How Long to Cook a Meatloaf

I cook my southern-style meatloaf recipe in a 8×8 glass dish. I use about 1.5 pounds of ground beef and it feeds my family of 6, plus a little leftover. If you want even more leftovers, I would make at least 2 pounds.

This recipe calls for your meatloaf to cook at a lower temperature, longer. I feel like this makes for a more moist meatloaf – no true southern lady would ever serve you a dry meatloaf!

For 1-2 pounds of meatloaf, you should cook the 8×8 glass pan for about 1-1.5 hours on 350 degrees, time varies depending on your oven, but this is what times work best for me.

When it comes to meatloaf, I don’t want it super soggy, but not too dry either. This recipe is just perfect, in my opinion, and makes for an easy meatloaf recipe for any night of the week!

What to Serve with Meatloaf

This classic southern meatloaf recipe deserves only the best side dishes. In the south, you’ll always find some form of potato beside a meatloaf. While I love to make mashed potatoes and green beans on meatloaf night, I also have another potato favorite.

These oven roasted mini potatoes with carrots are a perfect meatloaf side dish! They compliment the juicy meatloaf and give off a southern twist to the side dish variety. I bake them right alongside my meatloaf so they’re both perfectly cooked at about the same time.

Some of my other favorites to serve with meatloaf are:

• Instant Pot Broccoli
• Mashed Potatoes
• Green Beans
• Air Fryer Baked Potatoes
• Butternut Squash Macaroni and Cheese

Best Way to Reheat Meatloaf

There are certain meals that I make when I purposefully make too much food so we can have leftovers and this easy meatloaf recipe is one of them. There’s just nothing like a good leftover meatloaf sandwich on white bread! Is that a Southern thing? White bread or not, meatloaf makes great leftovers!

You have a few choices when it comes to reheating meatloaf. I think the best way to reheat meatloaf is in the oven. But how long to reheat meatloaf in oven? It will depend on if it’s still in the original pan or sliced, but about 10-15 minutes at 350 degrees should warm it just fine.

You could also put it in the microwave for a minute or two – or even the air fryer! I love this option as it crisps the meatloaf slices just a bit.

If you love classic comfort food and this southern-style meatloaf, you should check out some of my other favorite recipes!

Applewood Bacon Wrapped Pork Loin Filet

Southern Chicken Casserole

Sweet Southern Cole Slaw